{Reference Type}: Journal Article
{Title}: Current research status of TNFAIP8 in tumours and other inflammatory conditions (Review).
{Author}: Hua J;Zhuang G;Qi Z;
{Journal}: Int J Oncol
{Volume}: 59
{Issue}: 1
{Year}: Jul 2021
{Factor}: 5.884
{DOI}: 10.3892/ijo.2021.5226
{Abstract}: Tumour necrosis factor (TNF)‑α‑inducible protein 8 (TNFAIP8) is the founding member of the TIPE family. According to accumulating evidence, TNFAIP8 plays a pivotal role in the regulation of a variety of tumours, as well as inflammatory diseases. TNFAIP8 is suggested to act as an anti‑apoptotic protein, affecting proliferation, metastasis, invasion, angiogenesis, drug resistance and immune response through multiple signalling pathways. From the clinical point of view, further studies should be required to confirm the prognostic value of TNFAIP8 and also clarify its possible contribution to the development of a novel therapeutic strategy to treat patients with tumours, including those of the breast, colon and lung, and inflammatory diseases. The present review focuses on the TIPE family member TNFAIP8 and describes the molecular mechanisms with regard to how TNFAIP8 could participate in the development of tumours as well as other conditions.