{Reference Type}: Journal Article {Title}: Management of a case of Enhanced S-cone syndrome with massive foveoschisis treated with pars plana vitrectomy with silicone oil tamponade. {Author}: Bechet L;Atia R;Zeitz C;Mohand-Saïd S;Sahel JA;Barale PO;Audo I; {Journal}: Ophthalmic Genet {Volume}: 42 {Issue}: 5 {Year}: 10 2021 {Factor}: 1.274 {DOI}: 10.1080/13816810.2021.1925927 {Abstract}: Introduction: Goldmann Favre Syndrome (GFS) is a vitreoretinal degenerative disease with macular retinoschisis. The current treatment of foveoschisis is topical and oral carbonic anhydrase inhibitors.Case: A 22-year-old male diagnosed with GFS presented a progressive decrease in vision of the right eye. The optical coherence tomography showed a significant macular schisis. A medical treatment with topical and oral carbonic anhydrase inhibitors was ineffective. We performed a pars plana vitrectomy and silicone oil placement which led to an improvement of the visual acuity and a reduction of the foveoschisis.Conclusion: We describe here the first case of surgical treatment for macular schisis in a patient with GFS.