{Reference Type}: Journal Article
{Title}: Dalbavancin treatment for prosthetic joint infections in real-life: a national cohort study and literature review.
{Author}: Matt M;Duran C;Courjon J;Lotte R;Moing VL;Monnin B;Pavese P;Chavanet P;Khatchatourian L;Tattevin P;Cattoir V;Lechiche C;Illes G;Lacassin-Beller F;Senneville E;Dinh A; ;
{Journal}: J Glob Antimicrob Resist
{Volume}: 25
{Issue}: 0
{Year}: 06 2021
{Factor}: 4.349
{DOI}: 10.1016/j.jgar.2021.03.026
{Abstract}: Dalbavancin is a long-lasting lipoglycopeptide active against Gram-positive bacteria, especially methicillin-resistant staphylococci. Few data are available on dalbavancin use for treatment of prosthetic joint infections (PJIs). We describe a cohort of patients treated for PJI with dalbavancin and review the literature regarding this condition.<BR>All adult patients with PJI from the French dalbavancin national cohort from 1 June 2017 to 1 January 2019 were included. We collected clinical and microbiological characteristics and outcome through a standardised questionnaire. Clinical cure was defined as absence of clinical signs of infection at last visit. Failure was a composite criterion defined by persistence or reappearance of signs of infection, and/or switch to suppressive antibiotic treatment and/or death from infection. The literature review was performed using PubMed.<BR>Seventeen patients were included. Bacteria were identified in 16 cases: Staphylococcus aureus (n = 10), including methicillin-resistant S. aureus (n = 1); and coagulase-negative staphylococci (n = 10), including methicillin-resistant Staphylococcus epidermidis (n = 4). Sixteen patients (94.1%) had received antibiotic therapy prior to dalbavancin use (mean of 2.2 ± 1.3 lines). Clinical cure was achieved in 8/17 patients after a median follow-up of 299.0 (IQR 97.0-476.0) days. We reviewed all cases of PJI treated with dalbavancin available in the literature and the overall clinical cure was estimated at 73.1%.<BR>Our study and literature data suggest that use of dalbavancin in PJI could be considered, even as salvage therapy. Dalbavancin appears to be a safe and easy treatment for patients with staphylococcal PJIs.