{Reference Type}: Journal Article
{Title}: Multimechanistic Monoclonal Antibody Combination Targeting Key Staphylococcus aureus Virulence Determinants in a Rabbit Model of Prosthetic Joint Infection.
{Author}: Mao Y;Valour F;Nguyen NTQ;Doan TMN;Koelkebeck H;Richardson C;Cheng LI;Sellman BR;Tkaczyk C;Diep BA;
{Journal}: Antimicrob Agents Chemother
{Volume}: 65
{Issue}: 7
{Year}: 06 2021 17
{Factor}: 5.938
{DOI}: 10.1128/AAC.01832-20
{Abstract}: In a rabbit model of methicillin-resistant Staphylococcus aureus prosthetic joint infection (PJI), prophylaxis with AZD6389*-a combination of three monoclonal antibodies targeting alpha-hemolysin, bicomponent cytotoxins (LukSF/LukED/HlgAB/HlgCB), and clumping factor A-resulted in significant reductions in joint swelling, erythema, intra-articular pus, and bacterial burden in synovial tissues and biofilm-associated prosthetic implants compared with isotype-matched control IgG. Targeting specific staphylococcal virulence factors may thus have potential clinical utility for prevention of PJI.