{Reference Type}: Journal Article
{Title}: Multimodal assessment of disease activity in glioblastoma : A single center experience.
{Author}: Tinchon A;Marhold F;Calabek-Wohinz B;Hainz K;Tesar-Pelz M;Minear G;Freydl E;Blauensteiner K;Heinz G;Oberndorfer S;
{Journal}: Wien Klin Wochenschr
{Volume}: 133
{Issue}: 21
{Year}: Nov 2021
{Factor}: 2.275
{DOI}: 10.1007/s00508-021-01859-2
{Abstract}: <B>BACKGROUND: </B>Assessment of disease activity in glioblastoma (GBM) can be challenging due to several clinical and radiological pitfalls. Besides MRI, FET-PET and neurocognitive assessment (NA) are used in several neuro-oncological centers in order to improve the specificity of response assessment. We performed a retrospective study to investigate whether the assessment by RANO (Response Assessment in NeuroOncology) corresponds to FET-PET imaging and NA results. Moreover, the concordance of RANO with a final recommendation of an interdisciplinary neuro-oncological tumor board recommendation (TBR) was analyzed.<BR><B>METHODS: </B>We enrolled 25 consecutive patients with newly diagnosed histologically confirmed GBM in a pilot study, accounting for 81 multimodal test results. All patients were selected after undergoing consecutive follow-up comprising MRI, FET-PET, and NA with a subsequent TBR. Results were analyzed for correlations between RANO, FET-PET and NA. An additional consistency analysis was performed to elucidate the impact of RANO on decision making.<BR><B>RESULTS: </B>A highly statistically significant correlation was found between RANO and FET-PET and NA results (all P < 0.01); however, 26% of follow-up tests exhibited inconsistent results in multimodal assessment, among which RANO was only 48% in accordance with the final TBR. The concordance of NA and FET-PET with the final TBR was 67% and 86%, respectively.<BR><B>CONCLUSIONS: </B>The RANO proved its value in the context of multimodal assessment of disease activity in GBM; however, because the implementation of multimodal assessment showed a considerably high percentage of inconsistent results, further studies are required to investigate the relationship between different assessment techniques, in addition to their overall significance to response rating.