{Reference Type}: Comparative Study
{Title}: Breast Textured Implants Determine Early T-helper Impairment: BIAL2.20 Study.
{Author}: Vanni G;Materazzo M;Pellicciaro M;Amir S;Tacconi F;Ambrogi V;Buonomo OC;
{Journal}: Anticancer Res
{Volume}: 41
{Issue}: 4
{Year}: Apr 2021
{Factor}: 2.435
{DOI}: 10.21873/anticanres.14984
{Abstract}: <B>OBJECTIVE: </B>Surgical stress has been correlated with higher rate of postoperative complications. Breast implants' surfaces (textured or smooth) represent an immunological stimulus. Our prospective study (BIAL2.20) evaluated post-operative leukocytes response at baseline and postoperative day (POD) 1 and 2 after implant-based breast reconstruction.<BR><B>METHODS: </B>Between January and July 2020, 41 patients underwent reconstruction with textured (n=23) or smooth (n=18) implants. A full blood count and lymphocyte subsets were collected before surgery, on POD1 and POD2. Data were evaluated as difference and relative difference from baseline by two-way analysis of variance test (2-way-ANOVA). Mann-Whitney U-test was performed at each POD, whenever between-group 2-way-ANOVA reached statistical significance.<BR><B>RESULTS: </B>Within-group-analysis showed statistically significant total leukocytosis in both groups. Within-group-analysis of lymphocytes subsets demonstrated statistically significant lymphopenia in the textured group for T-lymphocytes, and T-helper cells. Between-group-analysis showed statistically significant lymphopenia in T-helper subsets in the textured group at POD1 and POD2, when compared with the smooth group.<BR><B>CONCLUSIONS: </B>Textured implants demonstrated a statistically significant impairment of T-helper trend during POD1 and POD2 when compared to smooth implants by between-group 2-way-ANOVA.