{Reference Type}: Journal Article
{Title}: A Phenome-Wide Association Study (PheWAS) of COVID-19 Outcomes by Race Using the Electronic Health Records Data in Michigan Medicine.
{Author}: Salvatore M;Gu T;Mack JA;Prabhu Sankar S;Patil S;Valley TS;Singh K;Nallamothu BK;Kheterpal S;Lisabeth L;Fritsche LG;Mukherjee B;
{Journal}: J Clin Med
{Volume}: 10
{Issue}: 7
{Year}: Mar 2021 25
{Factor}: 4.964
{DOI}: 10.3390/jcm10071351
{Abstract}: <B>BACKGROUND: </B>We performed a phenome-wide association study to identify pre-existing conditions related to Coronavirus disease 2019 (COVID-19) prognosis across the medical phenome and how they vary by race.<BR><B>METHODS: </B>The study is comprised of 53,853 patients who were tested/diagnosed for COVID-19 between 10 March and 2 September 2020 at a large academic medical center.<BR><B>RESULTS: </B>Pre-existing conditions strongly associated with hospitalization were renal failure, pulmonary heart disease, and respiratory failure. Hematopoietic conditions were associated with intensive care unit (ICU) admission/mortality and mental disorders were associated with mortality in non-Hispanic Whites. Circulatory system and genitourinary conditions were associated with ICU admission/mortality in non-Hispanic Blacks.<BR><B>CONCLUSIONS: </B>Understanding pre-existing clinical diagnoses related to COVID-19 outcomes informs the need for targeted screening to support specific vulnerable populations to improve disease prevention and healthcare delivery.