{Reference Type}: Journal Article
{Title}: Molecular epidemiology of Mycobacterium tuberculosis in Brazil before the whole genome sequencing era: a literature review.
{Author}: Conceição EC;Salvato RS;Gomes KM;Guimarães AEDS;da Conceição ML;Souza E Guimarães RJP;Sharma A;Furlaneto IP;Barcellos RB;Bollela VR;Anselmo LMP;Sisco MC;Niero CV;Ferrazoli L;Refrégier G;Lourenço MCDS;Gomes HM;de Brito AC;Catanho M;Duarte RS;Suffys PN;Lima KVB;
{Journal}: Mem Inst Oswaldo Cruz
{Volume}: 116
{Issue}: 0
{Year}: 2021
{Factor}: 2.747
{DOI}: 10.1590/0074-02760200517
{Abstract}: Molecular-typing can help in unraveling epidemiological scenarios and improvement for disease control strategies. A literature review of Mycobacterium tuberculosis transmission in Brazil through genotyping on 56 studies published from 1996-2019 was performed. The clustering rate for mycobacterial interspersed repetitive units - variable tandem repeats (MIRU-VNTR) of 1,613 isolates were: 73%, 33% and 28% based on 12, 15 and 24-loci, respectively; while for RFLP-IS6110 were: 84% among prison population in Rio de Janeiro, 69% among multidrug-resistant isolates in Rio Grande do Sul, and 56.2% in general population in São Paulo. These findings could improve tuberculosis (TB) surveillance and set up a solid basis to build a database of Mycobacterium genomes.