{Reference Type}: Journal Article
{Title}: Comparison of three biopsy forceps for hysteroscopic endometrial biopsy in postmenopausal patients (HYGREB-1): A multicenter, single-blind randomized clinical trial.
{Author}: Vitale SG;Laganà AS;Caruso S;Garzon S;Vecchio GM;La Rosa VL;Casarin J;Ghezzi F;
{Journal}: Int J Gynaecol Obstet
{Volume}: 155
{Issue}: 3
{Year}: Dec 2021
{Factor}: 4.447
{DOI}: 10.1002/ijgo.13669
{Abstract}: <B>OBJECTIVE: </B>To compare three types of biopsy forceps for hysteroscopic endometrial biopsy in postmenopausal women.<BR><B>METHODS: </B>Postmenopausal women undergoing operative hysteroscopy with endometrial biopsy for abnormal uterine bleeding or endometrial thickness (≥5 mm) were included. Operative hysteroscopy with endometrial biopsy was performed by hysteroscopic forceps. Women were randomized (1:1:1 ratio) in three groups and allocated to undergo endometrial biopsy by hysteroscopy using spoon, alligator, or snake forceps.<BR><B>RESULTS: </B>Seventy-five women were included in the study, 25 in each group. The duration of the biopsy was comparable between the three groups (P = 0.334) with a median of 180 seconds (range 20-480 seconds). No differences were observed about the number of attempts (P = 0.602), the use of another instrument (P = 0.276), and the biopsy appropriateness (P = 0.592). The spoon forceps group reported higher levels of pain compared to the alligator and snake forceps groups (P < 0.001). The spoon forceps received significantly lower scores by the operator compared to the alligator and snake forceps (P < 0.001). The alligator and snake forceps reported wider biopsy than the spoon forceps (P < 0.001).<BR><B>CONCLUSIONS: </B>Snake and alligator hysteroscopic forceps may be considered the first choice to perform an endometrial biopsy in postmenopausal women. ClinicalTrials.gov: NCT03427957.