{Reference Type}: Journal Article
{Title}: Dipylidium caninum draft genome - a new resource for comparative genomic and genetic explorations of flatworms.
{Author}: Liu GH;Korhonen PK;Young ND;Lu J;Wang T;Fu YT;Koehler AV;Hofmann A;Chang BCH;Wang S;Li N;Lin CY;Zhang H;Xiangli L;Lin L;Liu WM;Li N;Li HW;Gasser RB;Zhu XQ;
{Journal}: Genomics
{Volume}: 113
{Issue}: 3
{Year}: May 2021
{Factor}: 4.31
{DOI}: 10.1016/j.ygeno.2021.02.019
{Abstract}: Here, we present a draft genome of the tapeworm Dipylidium caninum (family Dipylidiidae) and compare it with other cestode genomes. This draft genome of D. caninum is 110 Mb in size, has a repeat content of ~13.4% and is predicted to encode ~10,000 protein-coding genes. We inferred excretory/secretory molecules (representing the secretome), other key groups of proteins (including peptidases, kinases, phosphatases, GTPases, receptors, transporters and ion-channels) and predicted potential intervention targets for future evaluation. Using 144 shared single-copy orthologous sequences, we investigated the genetic relationships of cestodes for which nuclear genomes are available. This study provides first insights into the molecular biology of D. caninum and a new resource for comparative genomic and genetic explorations of this and other flatworms.