{Reference Type}: Journal Article
{Title}: Infectious complications associated with short-term mechanical circulatory support in urgent heart transplant candidates.
{Author}: Solla-Buceta M;González-Vílchez F;Almenar-Bonet L;Lambert-Rodríguez JL;Segovia-Cubero J;González-Costello J;Delgado JF;Pérez-Villa F;Crespo-Leiro MG;Rangel-Sousa D;Martínez-Sellés M;Rábago-Juan-Aracil G;De-la-Fuente-Galán L;Blasco-Peiró T;Hervás-Sotomayor D;Garrido-Bravo IP;Mirabet-Pérez S;Muñiz J;Barge-Caballero E;
{Journal}: Rev Esp Cardiol (Engl Ed)
{Volume}: 0
{Issue}: 0
{Year}: Feb 2021 26
暂无{DOI}: 10.1016/j.rec.2020.11.019
{Abstract}: <B>OBJECTIVE: </B>Short-term mechanical circulatory support is frequently used as a bridge to heart transplant in Spain. The epidemiology and prognostic impact of infectious complications in these patients are unknown.<BR><B>METHODS: </B>Systematic description of the epidemiology of infectious complications and analysis of their prognostic impact in a multicenter, retrospective registry of patients treated with short-term mechanical devices as a bridge to urgent heart transplant from 2010 to 2015 in 16 Spanish hospitals.<BR><B>RESULTS: </B>We studied 249 patients, of which 87 (34.9%) had a total of 102 infections. The most frequent site was the respiratory tract (n=47; 46.1%). Microbiological confirmation was obtained in 78 (76.5%) episodes, with a total of 100 causative agents, showing a predominance of gram-negative bacteria (n=58, 58%). Compared with patients without infection, those with infectious complications showed higher mortality during the support period (25.3% vs 12.3%, P=.009) and a lower probability of receiving a transplant (73.6% vs 85.2%, P=.025). In-hospital posttransplant mortality was similar in the 2 groups (with infection: 28.3%; without infection: 23.4%; P=.471).<BR><B>CONCLUSIONS: </B>Patients supported with temporary devices as a bridge to heart transplant are exposed to a high risk of infectious complications, which are associated with higher mortality during the organ waiting period.