{Reference Type}: Case Reports
{Title}: Treatment of pediatric intracranial dissecting aneurysm with clipping and angioplasty, and next-generation sequencing analysis: A case report and literature review.
{Author}: Sun N;Yang XY;Zhao Y;Zhang QJ;Ma X;Wei ZN;Li MQ;
{Journal}: World J Clin Cases
{Volume}: 9
{Issue}: 5
{Year}: Feb 2021 16
{Factor}: 1.534
{DOI}: 10.12998/wjcc.v9.i5.1103
{Abstract}: <B>BACKGROUND: </B>Large intracranial dissecting aneurysm (IDA) in the anterior cerebral circulation is rare in children. There has been no consensus on the diagnosis and treatment for IDA in children.<BR><B>METHODS: </B>We report a 3-year-old boy with a large ruptured IDA in the right middle cerebral artery (16 mm × 14 mm). The IDA was successfully managed with clipping and angioplasty. Next-generation sequencing of the blood sample followed by bioinformatics analysis suggested that the rs78977446 variant of the ADAMTS13 gene is a risk for pediatric IDA. Three years after surgery, the boy was develop-mentally normal.<BR><B>CONCLUSIONS: </B>Clipping and angioplasty are effective treatments for ruptured IDA in the anterior cerebral circulation. ADAMTS13 rs78977446 is a risk factor for pediatric IDA.