{Reference Type}: Journal Article
{Title}: Dump the "dimorphism": Comprehensive synthesis of human brain studies reveals few male-female differences beyond size.
{Author}: Eliot L;Ahmed A;Khan H;Patel J;
{Journal}: Neurosci Biobehav Rev
{Volume}: 125
{Issue}: 0
{Year}: 06 2021
{Factor}: 9.052
{DOI}: 10.1016/j.neubiorev.2021.02.026
{Abstract}: With the explosion of neuroimaging, differences between male and female brains have been exhaustively analyzed. Here we synthesize three decades of human MRI and postmortem data, emphasizing meta-analyses and other large studies, which collectively reveal few reliable sex/gender differences and a history of unreplicated claims. Males' brains are larger than females' from birth, stabilizing around 11 % in adults. This size difference accounts for other reproducible findings: higher white/gray matter ratio, intra- versus interhemispheric connectivity, and regional cortical and subcortical volumes in males. But when structural and lateralization differences are present independent of size, sex/gender explains only about 1% of total variance. Connectome differences and multivariate sex/gender prediction are largely based on brain size, and perform poorly across diverse populations. Task-based fMRI has especially failed to find reproducible activation differences between men and women in verbal, spatial or emotion processing due to high rates of false discovery. Overall, male/female brain differences appear trivial and population-specific. The human brain is not "sexually dimorphic."