{Reference Type}: Journal Article
{Title}: Plexus-specific retinal capillary avascular area in exudative age-related macular degeneration with projection-resolved OCT angiography.
{Author}: Gao L;Wang J;You Q;Guo Y;Flaxel CJ;Hwang TS;Huang D;Jia Y;Bailey ST;
{Journal}: Br J Ophthalmol
{Volume}: 0
{Issue}: 0
{Year}: Dec 2020 22
{Factor}: 5.908
{DOI}: 10.1136/bjophthalmol-2020-317562
{Abstract}: <B>OBJECTIVE: </B>To detect the plexus-specific retinal capillary avascular area in exudative age-related macular degeneration (EAMD) with projection-resolved optical coherence tomography angiography (PR-OCTA).<BR><B>UNASSIGNED: </B>In this prospective cross-sectional single centre study, eyes with treatment-naïve EAMD underwent macular 3×3 mm OCTA with AngioVue system. OCTA scans were analysed and processed including three-dimensional projection artefact removal, retinal layer semi-automated segmentation and en face angiogram generation. Automated quantification of extrafoveal (excluding the central 1 mm circle) avascular area (EAA) were calculated on projection-resolved superficial vascular complex (SVC), intermediate capillary plexus (ICP) and deep capillary plexus (DCP), respectively.<BR><B>RESULTS: </B>Nineteen eyes with EAMD and 19 age-matched healthy control eyes were included. There was no significant difference between the EAMD and control eyes in terms of age, sex, axial length and mean ocular perfusion pressure (all p>0.05). Compared with control eyes, EAMD eyes had significantly larger EAA in SVC (median 0.125 vs 0.059 mm2, p=0.006), ICP (0.016 vs 0.000 mm2, p=0.004) and DCP (0.033 vs 0.000 mm2, p＜0.001).<BR><B>CONCLUSIONS: </B>PR-OCTA showed that EAMD is associated with focal avascular area in all the three retinal vascular plexuses.