{Reference Type}: Journal Article
{Title}: The drug likeness analysis of anti-inflammatory clerodane diterpenoids.
{Author}: Feng Z;Cao J;Zhang Q;Lin L;
{Journal}: Chin Med
{Volume}: 15
{Issue}: 1
{Year}: Dec 2020 9
{Factor}: 4.546
{DOI}: 10.1186/s13020-020-00407-w
{Abstract}: Inflammation is an active defense response of the body against external stimuli. Long term low-grade inflammation has been considered as a deteriorated factor for aging, cancer, neurodegeneration and metabolic disorders. The clinically used glucocorticoids and non-steroidal anti-inflammatory drugs are not suitable for chronic inflammation. Therefore, it's urgent to discover and develop new effective and safe drugs to attenuate inflammation. Clerodane diterpenoids, a class of bicyclic diterpenoids, are widely distributed in plants of the Labiatae, Euphorbiaceae and Verbenaceae families, as well as fungi, bacteria, and marine sponges. Dozens of anti-inflammatory clerodane diterpenoids have been identified on different assays, both in vitro and in vivo. In the current review, the up-to-date research progresses of anti-inflammatory clerodane diterpenoids were summarized, and their druglikeness was analyzed, which provided the possibility for further development of anti-inflammatory drugs.