{Reference Type}: Journal Article
{Title}: Alatains A and B, unique hetero-dimeric polyphenols from Cassia alata and their anti-tobacco mosaic virus activity.
{Author}: Zhou M;Liu C;Yang J;Niu D;Dong M;Yang G;Li X;Hu Q;
{Journal}: Fitoterapia
{Volume}: 147
{Issue}: 0
{Year}: Nov 2020
{Factor}: 3.204
{DOI}: 10.1016/j.fitote.2020.104763
{Abstract}: Two structurally unique polyphenols, alatains A (1) and B (2), were isolated from the bark of Cassia alata. Their structures were elucidated on the basis of spectroscopic analysis. Compounds 1 and 2 represent a new type of hetero-dimeric polyphenols with a C-14-C-5' linkage, biogenetically formed by an unusual intermolecular oxidative phenol-coupling reaction between a chromone unit and an isocoumarin moiety. Moreover, compounds 1 and 2 showed significant anti-tobacco mosaic virus (anti-TMV) inhibition IC50 values of 18.8 and 11.4 μM, respectively. Alatains A and B also exhibited promising protective effects on TMV infection of the host plants (Nicotiana tabacum) with the inhibition rates of 54.6% and 69.7% at the concentration of 20 μM, respectively. The results provided a new structural template for potential anti-TMV agent discovery.