{Reference Type}: Journal Article
{Title}: Optimal Maturation of the SIV-Specific CD8+ T Cell Response after Primary Infection Is Associated with Natural Control of SIV: ANRS SIC Study.
{Author}: Passaes C;Millet A;Madelain V;Monceaux V;David A;Versmisse P;Sylla N;Gostick E;Llewellyn-Lacey S;Price DA;Blancher A;Dereuddre-Bosquet N;Desjardins D;Pancino G;Le Grand R;Lambotte O;Müller-Trutwin M;Rouzioux C;Guedj J;Avettand-Fenoel V;Vaslin B;Sáez-Cirión A;
{Journal}: Cell Rep
{Volume}: 32
{Issue}: 12
{Year}: 09 2020 22
暂无{DOI}: 10.1016/j.celrep.2020.108174
{Abstract}: Highly efficient CD8+ T cells are associated with natural HIV control, but it has remained unclear how these cells are generated and maintained. We have used a macaque model of spontaneous SIVmac251 control to monitor the development of efficient CD8+ T cell responses. Our results show that SIV-specific CD8+ T cells emerge during primary infection in all animals. The ability of CD8+ T cells to suppress SIV is suboptimal in the acute phase but increases progressively in controller macaques before the establishment of sustained low-level viremia. Controller macaques develop optimal memory-like SIV-specific CD8+ T cells early after infection. In contrast, a persistently skewed differentiation phenotype characterizes memory SIV-specific CD8+ T cells in non-controller macaques. Accordingly, the phenotype of SIV-specific CD8+ T cells defined early after infection appears to favor the development of protective immunity in controllers, whereas SIV-specific CD8+ T cells in non-controllers fail to gain antiviral potency, feasibly as a consequence of early defects imprinted in the memory pool.