{Reference Type}: Journal Article
{Title}: A case-control study of microRNA polymorphisms in gastric cancer screening by SNP chip combined with time of flight mass spectrometry.
{Author}: Wu C;Han R;Yang S;Jiang Y;Shu Z;Liu J;Ji S;Yan W;Liu B;
{Journal}: Biomark Med
{Volume}: 14
{Issue}: 16
{Year}: 11 2020
{Factor}: 2.498
{DOI}: 10.2217/bmm-2020-0003
{Abstract}: Aims: To explore new SNP sites of miRNAs associated with gastric cancer, thereby providing valuable biomarkers to diagnose and screen gastric cancer. Materials & methods: A 1:1 case-control study was carried out. Microarrays were used to screen the SNP loci of miRNAs in the genomes of matched pairs of patients, 96 with gastric cancer and 96 healthy controls. For validation, mass spectrometry was used to classify miRNA SNP loci in 622 pairs of subjects. Results: rs7143252 was linked to a higher occurrence of gastric cancer. Conclusion: These results suggest that rs7143252 could be used as a specific biomarker to diagnose and screen gastric cancer.