{Reference Type}: Journal Article
{Title}: 2018-2019 Update on the Molecular Epidemiology of HIV-1 in Indonesia.
{Author}: Khairunisa SQ;Megasari NLA;Ueda S;Budiman W;Kotaki T;Nasronudin ;Kameoka M;
{Journal}: AIDS Res Hum Retroviruses
{Volume}: 36
{Issue}: 11
{Year}: 11 2020
{Factor}: 1.723
{DOI}: 10.1089/AID.2020.0151
{Abstract}: The HIV type 1 (HIV-1) epidemic has continued to grow in Indonesia; however, continuous updates on the epidemiology of HIV-1 in Indonesia remain challenging because it is the biggest archipelago in the world. Furthermore, the emergence of HIV drug resistance (HIVDR) has had a negative impact on the treatment of infected individuals. In this study, we performed HIV-1 subtyping and the detection of HIVDR in 105 HIV-1-infected individuals residing in various cities in Indonesia during 2018-2019. The results obtained identified CRF01_AE as the major epidemic HIV-1 strain, responsible for 81.9% of infection cases, followed by subtype B (12.4%), CRF02_AG (3.8%), CRF52_01B (1%), and a recombinant between CRF01_AE and CRF02_AG (1.0%). Major drug resistance-associated mutations against reverse transcriptase inhibitors were detected in 20% of samples. These results suggest that CRF01_AE is a major HIV-1 strain in Indonesia, while CRF02_AG is emerging. The prevalence of HIVDR in Indonesia needs to be monitored.