{Reference Type}: Journal Article
{Title}: Antileishmanial activity of long chain alkyl benzene and other constituents from seeds of Sesamum indicum. L (Pedaliaceae).
{Author}: Ma'mag LK;Zintchem AAA;Atchadé AT;Kopa Kowa T;Tchinda Tiabou A;Bikobo DSN;Pegnyemb DE;
{Journal}: Nat Prod Res
{Volume}: 35
{Issue}: 23
{Year}: Dec 2021
{Factor}: 2.488
{DOI}: 10.1080/14786419.2020.1793147
{Abstract}: The methanolic extract of the waste seeds of Sesamum indicum L. (Pedaliaceae) was subjected to chromatographic fractionation; it led to the isolation of an alkyl benzene identified as 1,3-bis (pentadecyl)benzene (1) along with three known fatty acids: oleic acid (2), linoleic acid (3), and palmitic acid (4); one monosaturated cardanol, 3-pentadecylphenol (5) and two phytosteroids identified as sitostanol (6) and campestanol (7). The structures of these compounds were elucidated by chemical and spectroscopic analyses. Compounds 1, 5 and 6 were evaluated against protozoan parasites. Compound 1 moderately inhibited the promastigote form of Leishmania donovani LG13 with IC50 equal to 16.9 μM.