{Reference Type}: Case Reports
{Title}: A young male with chronic nonproductive cough diagnosed with blastomycosis in China: a case report.
{Author}: Wang N;Luo Z;Deng S;Li Q;
{Journal}: BMC Pulm Med
{Volume}: 20
{Issue}: 1
{Year}: Jul 2020 11
{Factor}: 3.32
{DOI}: 10.1186/s12890-020-01225-4
{Abstract}: <B>BACKGROUND: </B>Blastomycosis is a fungal infectious disease prevalent in North America and rarely reported in Asia. Misdiagnosis of malignancy and other infectious diseases were reported.<BR><B>METHODS: </B>A 24-years-old male patient presented with chronic non-productive cough of 4 months duration. He had been diagnosed with Mycobacterium tuberculosis infection and lung malignancy elsewhere and presented to us as the symptoms persisted. We offered him the biopsy under endobronchial ultrasound-guide sheath-transbronchial lung biopsy and sample specimen were sent for next generation sequencing analysis, returned as Blastomyces Dermatitidis infection. The patient was treated by itraconazole for 6 months, his symptoms decreased significantly and the CT scan showed resolution of the lesion.<BR><B>CONCLUSIONS: </B>We shared a case of blastomycosis with delayed and difficult diagnosis and reviewed the knowledge regarding differential diagnosis and next generation sequencing technologies.