{Reference Type}: Journal Article
{Title}: The Structural-Functional Damage of Fibrinogen Oxidized by Hydrogen Peroxide.
{Author}: Yurina LV;Vasilyeva AD;Kononenko VL;Bugrova AE;Indeykina MI;Kononikhin AS;Nikolaev EN;Rosenfeld MA;
{Journal}: Dokl Biochem Biophys
{Volume}: 492
{Issue}: 1
{Year}: May 2020
{Factor}: 0.834
{DOI}: 10.1134/S1607672920020167
{Abstract}: The effect of peroxide-induced oxidation of fibrinogen on modification of its primary structure and functional properties was investigated. The oxidation sites were shown to be Met, Trp, and His residues. Using the DLS method, it was found that the oxidative modification of fibrinogen results in the change of microrheological characteristics of fibrin network. The fibrinogen oxidation diminishes its tolerance to plasmin hydrolysis and deteriorates the factor XIIIa ability to stabilize the fibrin gel.