{Reference Type}: Journal Article
{Title}: Detection rate, pattern of relapse and influence on therapeutic decision of PSMA PET/CT in patients affected by biochemical recurrence after radical prostatectomy, a retrospective case series.
{Author}: Francolini G;Detti B;Bottero M;Zilli T;Lancia A;Bruni A;Borghesi S;Mariotti M;Castellucci P;Fanti S;Filippi AR;Teriaca MA;Maragna V;Aristei C;Mazzeo E;Livi L;Ingrosso G;
{Journal}: Clin Transl Oncol
{Volume}: 23
{Issue}: 2
{Year}: Feb 2021
{Factor}: 3.34
{DOI}: 10.1007/s12094-020-02427-2
{Abstract}: <B>OBJECTIVE: </B>68Ga-Prostate-specific membrane antigen (PSMA) PET/CT is widely used in patients with biochemical recurrence (BCR) after radical prostatectomy. We collected data about patients staged with PSMA PET/CT after BCR (PSA < 1 ng/ml) in four different institutes. Impact of baseline features (Gleason score, risk classification, PSA at recurrence, PSA doubling time and time to recurrence) was explored to understand predictive factors of (PSMA) PET/CT positivity. Impact of restaging on following treatment approaches was reported.<BR><B>RESULTS: </B>92 patients were included. PSMA PET/CT detection rate was 56.5% and low-volume disease (≤ 3 non-visceral lesions) was detected in 52.2% of patients. After positive scan, 13.5% of patients still lies on observation, ADT alone was administered in 30.8% of cases, Stereotactic body RT (SBRT) alone was delivered to 44.2% of patients and 11.5% of patients underwent concomitant SBRT and ADT. Seven patients underwent conventional salvage prostate bed RT. Chi-squared test showed a higher rate of positive PSMA PET/CT for patients with Gleason score > 7 (p = 0.004) and TTR < 29.5 months (p = 0.003).<BR><B>CONCLUSIONS: </B>PSMA PET/CT showed a high detection rate. This influenced clinical management in a significant percentage of patients, allowing treatment tailoring on the basis of imaging.