{Reference Type}: Journal Article {Title}: Evidence Review for Centers for Disease Control and Prevention Guidance Development on Laboratory Testing to Detect Treponema pallidum Infection (Syphilis). {Author}: Kersh EN;Workowski KA; {Journal}: Clin Infect Dis {Volume}: 71 {Issue}: 0 {Year}: 06 2020 24 {Factor}: 20.999 {DOI}: 10.1093/cid/ciaa348 {Abstract}: The articles in this supplement address key questions on syphilis diagnostics, provide reference tables of test performances, and discuss optimal specimens and knowledge gaps. Laboratory-developed genetic direct detection tests could be most useful at the point of care and add to the currently available serologic methods of nontreponemal and treponemal tests.