{Reference Type}: Case Reports
{Title}: Rapid Diagnosis of a Family Cluster of Pertussis Starting from a Child: a Case Report.
{Author}: Yang SY;Zhang HM;Pang L;Wang LH;
{Journal}: Clin Lab
{Volume}: 66
{Issue}: 6
{Year}: Jun 2020 1
{Factor}: 1.053
{DOI}: 10.7754/Clin.Lab.2019.191110
{Abstract}: <B>BACKGROUND: </B>Pertussis, caused by Bordetella pertussis (B. pertussis), is a highly transmissible, acute respiratory disease that occurs in many countries. Diagnosis of pertussis continues to be a challenge using traditional tests due to their turn-around time and sensitivity. Herein, we rapidly and accurately screened a family cluster of pertussis from a child and her mother.<BR><B>METHODS: </B>We used an automated nested multiplex PCR system which included B. pertussis, influenza A virus, and 19 other respiratory pathogens.<BR><B>RESULTS: </B>We detected B. pertussis, influenza A virus H1-2009 (FluA-2009), adenovirus, and respiratory syncytial virus (RSV) in the child, and the mother of the child was positive for B. pertussis and FluA-2009.<BR><B>CONCLUSIONS: </B>Active and timely screening for pertussis of adult family members should be considered. The detection of multiple respiratory pathogens may guide effective antibiotic therapies. This could be a novel test for the prevention of pertussis.