{Reference Type}: Case Reports
{Title}: [Fatal intracerebral hemorrhage in a patient with chronic neutrophilic leukemia: About one case and literature review].
{Author}: Talon L;de Renzis B;Fiore M;Sanhes L;Sapin AF;Berger M;Sinègre T;Lebreton A;
{Journal}: Rev Med Interne
{Volume}: 41
{Issue}: 8
{Year}: Aug 2020
{Factor}: 0.885
{DOI}: 10.1016/j.revmed.2020.03.012
{Abstract}: <B>BACKGROUND: </B>Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative syndrome characterized by a significant increase in mature neutrophils. One of the most serious complications is the occurrence of bleeding events, which may sometimes lead to death.<BR><B>METHODS: </B>A 75-year-old patient presented with CNL, complicated by a severe bleeding phenotype. Biological investigations revealed platelet function defect and increase in neutrophil elastase. The follow-up was marked by an intracranial hemorrhage leading to the patient's death 7 months after diagnosis.<BR><B>CONCLUSIONS: </B>This bleeding phenotype has been reported several times in patients with CNL. However, the pathophysiological mechanisms that cause bleeding are not yet fully understood.