{Reference Type}: Case Reports
{Title}: An Unusual Case of the Successful Treatment of Carbapenem-resistant Ventriculitis with Intravenous Colistin.
{Author}: Abu Bakar A;Palaniandy K;Fadzil F;Jaafar AS;Paramasvaran S;
{Journal}: Cureus
{Volume}: 12
{Issue}: 2
{Year}: Feb 2020 27
暂无{DOI}: 10.7759/cureus.7120
{Abstract}: Ventriculitis is a well-documented complication of ventriculostomy, which is difficult to treat and is associated with high rates of mortality. There is a growing trend of resistance among many organisms, such as Acinetobacter baumannii, in particular, to most antibiotics with the exception of colistin. It is thought that colistin has poor blood-brain barrier penetration; therefore, in cases of ventriculitis, it is preferentially administered via the intrathecal or intraventricular route. These routes, in turn, risk introducing infections, which may perpetuate the problem. We report a case of multidrug-resistant Acinetobacter baumannii ventriculitis, which was treated successfully with intravenous colistin monotherapy.