{Reference Type}: Journal Article
{Title}: Ability of FFR-CT to detect the absence of hemodynamically significant lesions in patients with high-risk NSTE-ACS admitted in the emergency department with chest pain, study design and rationale.
{Author}: Meier D;Skalidis I;De Bruyne B;Qanadli SD;Rotzinger D;Eeckhout E;Collet C;Muller O;Fournier S;
{Journal}: Int J Cardiol Heart Vasc
{Volume}: 27
{Issue}: 0
{Year}: Apr 2020
暂无{DOI}: 10.1016/j.ijcha.2020.100496
{Abstract}: <B>BACKGROUND: </B>In the era of High-sensitive troponin (hs-Tn), up to 50% of patients with a mild increase of hs-Tn will finally have a normal invasive coronary angiogram. Fractional Flow Reserve (FFR) derived from coronary computed tomographic angiography (FFR-CT) has never been used as a non-invasive tool for the diagnosis of coronary artery disease in patients with high-risk acute coronary syndrome without ST segment elevation (NSTE-ACS).<BR><B>OBJECTIVE: </B>The study aims to determine the role of coronary CT angiography and FFR-CT in the setting of high-risk NSTE-ACS.<BR><B>METHODS: </B>We will conduct a prospective trial, enrolling 250 patients admitted with high-risk NSTE-ACS who will rapidly undergo a coronary CT angiography and then a coronary angiography with FFR measurements. Results of coronary CT, FFR-CT and coronary angiography (± FFR) will be compared.<BR><B>UNASSIGNED: </B>In conclusion, non-invasive identification of patients with high-risk NSTE-ACS who could avoid coronary angiography would reduce procedure related risks and medical costs.