{Reference Type}: Case Reports
{Title}: Durable response to combination radiotherapy and immunotherapy in EP-resistant lung large-cell neuroendocrine carcinoma with B2M and STK11 mutations: a case report.
{Author}: Qin Y;Yu M;Zhou L;Jiang L;Huang M;
{Journal}: Immunotherapy
{Volume}: 12
{Issue}: 4
{Year}: 03 2020
{Factor}: 4.04
{DOI}: 10.2217/imt-2019-0166
{Abstract}: Lung large-cell neuroendocrine carcinoma (LCNEC) is a rare tumor with poor prognosis. Despite the increasing prevalence of immune checkpoint inhibitors (ICIs) across a broad spectrum of solid tumors, very limited information is available about the efficacy in LCNEC. Here, we report a case of advanced lung LCNEC treated with combined radiotherapy and ICIs, which resulted in a durable response. We also focused on the impressive reaction of metastatic and primary lesions to two different combination modes of radiotherapy and ICIs.