{Reference Type}: Journal Article
{Title}: Consensus-based statements for the management of mitochondrial stroke-like episodes.
{Author}: Ng YS;Bindoff LA;Gorman GS;Horvath R;Klopstock T;Mancuso M;Martikainen MH;Mcfarland R;Nesbitt V;Pitceathly RDS;Schaefer AM;Turnbull DM;
{Journal}: Wellcome Open Res
{Volume}: 4
{Issue}: 0
{Year}: 2019
暂无{DOI}: 10.12688/wellcomeopenres.15599.1
{Abstract}: Background: Focal-onset seizures and encephalopathy are prominent features of a stroke-like episode, which is a severe neurological manifestation associated with subtypes of mitochondrial disease. Despite more than 30 years of research, the acute treatment of stroke-like episodes remains controversial. Methods: We used the modified Delphi process to harness the clinical expertise of a group of mitochondrial disease specialists from five European countries to produce consensus guidance for the acute management of stroke-like episodes and commonly associated complications. Results: Consensus on a new definition of mitochondrial stroke-like episodes was achieved and enabled the group to develop diagnostic criteria based on clinical features, neuroimaging and/or electroencephalogram findings. Guidelines for the management of strokelike episodes were agreed with aggressive seizure management strongly recommended at the outset of stroke-like episodes. Conclusions: Our consensus statement defines stroke-like episodes in terms of an epileptic encephalopathy and we have used this to revise both diagnostic criteria and guidelines for management. A prospective, multi-centre, randomised controlled trial is required for evaluating the efficacy of any compound on modifying the trajectory of stroke-like episodes.