{Reference Type}: Journal Article
{Title}: Implications of new understandings of gliomas in children and adults with NF1: report of a consensus conference.
{Author}: Packer RJ;Iavarone A;Jones DTW;Blakeley JO;Bouffet E;Fisher MJ;Hwang E;Hawkins C;Kilburn L;MacDonald T;Pfister SM;Rood B;Rodriguez FJ;Tabori U;Ramaswamy V;Zhu Y;Fangusaro J;Johnston SA;Gutmann DH;
{Journal}: Neuro Oncol
{Volume}: 22
{Issue}: 6
{Year}: 06 2020 9
{Factor}: 13.029
{DOI}: 10.1093/neuonc/noaa036
{Abstract}: Gliomas are the most common primary central nervous system tumors occurring in children and adults with neurofibromatosis type 1 (NF1). Over the past decade, discoveries of the molecular basis of low-grade gliomas (LGGs) have led to new approaches for diagnosis and treatments. However, these new understandings have not been fully applied to the management of NF1-associated gliomas. A consensus panel consisting of experts in NF1 and gliomas was convened to review the current molecular knowledge of NF1-associated low-grade "transformed" and high-grade gliomas; insights gained from mouse models of NF1-LGGs; challenges in diagnosing and treating older patients with NF1-associated gliomas; and advances in molecularly targeted treatment and potential immunologic treatment of these tumors. Next steps are recommended to advance the management and outcomes for NF1-associated gliomas.