{Reference Type}: Journal Article
{Title}: Sulfuryl Fluoride Mediated Synthesis of Amides and Amidines from Ketoximes via Beckmann Rearrangement.
{Author}: Gurjar J;Fokin VV;
{Journal}: Chemistry
{Volume}: 26
{Issue}: 46
{Year}: Aug 2020 17
{Factor}: 5.02
{DOI}: 10.1002/chem.201905358
{Abstract}: A metal-free and redox-neutral method for Beckmann rearrangement employing inexpensive and readily available SO2 F2 gas is described. The reported transformation proceeds at ambient temperature and is compatible with a wide range of sterically and electronically diverse aromatic, heteroaromatic, aliphatic and lignin-like oximes providing amides in good to excellent yields. The reaction proceeds through the formation of an imidoyl fluoride intermediate that can also be used for the synthesis of amidines.