{Reference Type}: Evaluation Study
{Title}: Effect of graft positioning on dissipated energy in knee osteochondral autologous transplantation-A biomechanical study.
{Author}: Walter C;Trappe D;Beck A;Jacob C;Hofmann UK;
{Journal}: J Orthop Res
{Volume}: 38
{Issue}: 8
{Year}: 08 2020
{Factor}: 3.102
{DOI}: 10.1002/jor.24612
{Abstract}: Focal cartilage defects can be treated by osteochondral autologous transplantation (OAT). High congruence of the graft with the surrounding cartilage structure is essential for a good clinical outcome, but can not always be achieved. We recently established a method to measure dissipated energy (DE) as a friction parameter in knee joints. We now investigated how autograft harvesting and implant positioning affect the DE during knee motion. Six sheep knee joints were cyclically motioned under 400 N axial load. During the cyclic motion, the flexion angle and the respective torque were recorded and the DE was calculated. Several experimental conditions were tested: first, the DE was measured after approach had been performed ("native"). Subsequently, a cylinder was removed from the medial femur condyles and a donor cylinder was inserted from an unloaded site in four different transplant positions: even, 1 mm deeper, 1 mm higher, and flush without cartilage (defect). No significant changes in friction were observed between the native knee and an even or deep OAT positioning. We, however, found a small but significant increase in DE between the "native" and "1 mm high" formations (ΔDE compared with native = 14 mJ/cycle; P = .004 after data normalization) and a large increase in defect situation (ΔDE compared with native = 119 mJ/cycle; P = .001). Considering the long-term therapeutic aim that is pursued when performing OAT, elevated graft positioning should clearly be avoided. From a biomechanical point of view, donor site morbidity after cylinder harvest can be neglected.