{Reference Type}: Clinical Trial
{Title}: Immunosuppressive therapy for elderly-acquired pure red cell aplasia: cyclosporine A may be more effective.
{Author}: Liu X;Lu X;Chen L;Yang Y;Wu X;Lu R;Wang S;Zhang J;Hong M;Zhu Y;He G;Li J;
{Journal}: Ann Hematol
{Volume}: 99
{Issue}: 3
{Year}: Mar 2020
{Factor}: 4.03
{DOI}: 10.1007/s00277-020-03926-6
{Abstract}: This current study retrospectively analyzed the clinical characteristics of 69 adult patients with acquired pure red cell aplasia (PRCA) including 40 elderly and 29 non-elderly patients from September 2009 to June 2019. The remission induction therapy regimens included cyclosporine A (CsA), corticosteroids (CS), or other immunosuppressive agents. The overall response rate was 55% (22/40) in the elderly group compared with 75.9% (22/29) in non-elderly patients (P = 0.075). In elderly patients, the best remission was achieved in the group treated with CsA than those treated with CS or other immunosuppressive agents (83.3% vs 26.7% vs 42.9%%, P = 0.004). However, outcomes of remission were similar among different treatment groups (P = 0.458) in non-elderly patients. CS induced a higher response rate in the non-elderly than that in the elderly (88.9% vs 26.7%, P = 0.009). By univariate and multivariate analysis, the clinical efficacy of elderly patients with acquired PRCA was closely associated with an induction regimen of CsA (P = 0.009; P = 0.017). In conclusion, CsA might produce higher response rate than CS and other drugs in elderly patients with acquired PRCA.