{Reference Type}: Journal Article
{Title}: New entry to the enantioselective formation of substituted cyclohexenes bearing an all-carbon quaternary stereogenic center.
{Author}: Komine K;Urayama Y;Hosaka T;Fukuda H;Hatakeyama S;Ishihara J;
{Journal}: Chirality
{Volume}: 32
{Issue}: 3
{Year}: 03 2020
{Factor}: 2.183
{DOI}: 10.1002/chir.23173
{Abstract}: Enantioselective formation of cyclohexene derivatives bearing an all-carbon quaternary stereogenic center is described. The racemic cyclohexenes are readily transformed to chiral substituted cyclohexenes in good yield with excellent enantioselectivity and diastereoselectivity by a palladium-mediated deracemization. The resulting products are promising synthetic intermediates of biologically active natural products. This protocol provides us with a new entry to the concise and scalable synthesis of multifunctionalized compounds.