{Reference Type}: Case Reports {Title}: Human pegivirus in brain tissue of a patient with encephalitis. {Author}: Tuddenham R;Eden JS;Gilbey T;Dwyer DE;Jennings Z;Holmes EC;Branley JM; {Journal}: Diagn Microbiol Infect Dis {Volume}: 96 {Issue}: 2 {Year}: Feb 2020 {Factor}: 2.983 {DOI}: 10.1016/j.diagmicrobio.2019.114898 {Abstract}: We describe a case of meningoencephalitis in which meta-transcriptomic (RNA) sequencing detected human pegivirus (HPgV) in brain tissue, cerebrospinal fluid, and serum in the absence of other pathogens. This is the first detection of HPgV in antemortem brain tissue, although it is uncertain whether HPgV is responsible for the observed encephalitis.