{Reference Type}: Journal Article
{Title}: Distinguishing Myth from Fact: Photocarcinogenesis and Phototherapy.
{Author}: Thompson KG;Kim N;
{Journal}: Dermatol Clin
{Volume}: 38
{Issue}: 1
{Year}: Jan 2020
{Factor}: 3.645
{DOI}: 10.1016/j.det.2019.08.003
{Abstract}: Ultraviolet (UV) radiation contributes to the development of skin cancer through direct and indirect DNA damage, production of reactive oxygen species, and local immunomodulation. The association between UV radiation and skin cancer has raised concern for the risk of carcinogenesis following phototherapy. The photocarcinogenic impact of psoralen and UVA radiation (PUVA) has been extensively studied, whereas limited safety studies exist for other phototherapy modalities, such as broadband and narrowband UVB and UVA1. Because of the as of yet unclear risk, patients who have undergone any type of phototherapy should be followed for age-appropriate skin cancer screening.