{Reference Type}: Journal Article
{Title}: Endoscopic alterations in Peyer's patches in patients with ulcerative colitis: A prospective, multicenter study.
{Author}: Hiyama S;Iijima H;Sakakibara Y;Yamada T;Mukai A;Otake Y;Yamaguchi T;Araki M;Kawai S;Tsujii Y;Inoue T;Hayashi Y;Shinzaki S;Takehara T;
{Journal}: J Gastroenterol Hepatol
{Volume}: 35
{Issue}: 7
{Year}: Jul 2020
{Factor}: 4.369
{DOI}: 10.1111/jgh.14933
{Abstract}: OBJECTIVE: Peyer's patches (PPs) play a major role in intestinal mucosal immunity; however, their role in ulcerative colitis (UC) is not well investigated. We evaluated endoscopic features of PPs on narrow-band imaging with magnifying endoscopy (NBI-ME) and investigated their association with clinical factors.
METHODS: We prospectively recruited 105 patients with UC, 18 with Crohn's disease, 16 with disease control, and 33 healthy control subjects at three institutions from 2014 to 2017. NBI-ME images of the villi of PPs were evaluated according to the Villi Index, and patients were divided into the Villi Index low (L) and high (H) types. The 1-year sustained clinical remission rate was evaluated between L-type and H-type PPs in patients with UC.
RESULTS: The proportions of patients with H-type PPs were significantly higher among UC, Crohn's disease, and disease control patients than among healthy control patients (P = 0.0125, 0.018, 0.0007). In UC, age, gender, endoscopic score, and extent of disease involvement were not significantly different between L-type and H-type PPs, whereas the sustained clinical remission rate was significantly higher in L-type PPs than in H-type PPs (88% [57/65] vs 65% [17/26], P = 0.019). Multivariate analysis revealed that the L type of PPs was a significant factor for sustained clinical remission (odds ratio 3.8, 95% confidence interval 1.1-12.9, P = 0.033).
CONCLUSIONS: Patients with UC showed endoscopic alterations in PPs on NBI-ME, and highly altered appearance of PPs can be associated with a high risk of clinical relapse in patients with UC.