{Reference Type}: Case Reports {Title}: Spontaneous resolution of prenatally diagnosed isolated pleural effusion: An unusual early sign of a newborn disease. {Author}: Kajdy A;Materny A;Modzelewski J;Baszczeska J;Rabijewski M;Szymkiewicz-Dangel J; {Journal}: J Obstet Gynaecol Res {Volume}: 45 {Issue}: 12 {Year}: Dec 2019 {Factor}: 1.697 {DOI}: 10.1111/jog.14113 {Abstract}: We present a case report of a fetus with a diagnosed pleural effusion in the first trimester on nuchal translucency scan. The effusion resolved spontaneously by 17 weeks of pregnancy. Toxoplasmosis, rubella, cytomegalovirus, herpes simplex (TORCH) - negative. Array comparative genomic hybridization (aCGH) - normal. Serial Doppler scans normal - no prenatal signs of anemia. Maternal antibodies against red cell antigens - negative. Delivery at term by cesarean section because of macrosomia. Neonate suffered from prolonged jaundice. At 3 weeks of life diagnosed with hereditary spherocytosis. Literature review shows that this may be the first connection between this disease and prenatal life.