{Reference Type}: Journal Article
{Title}: Development and validation of a new prediction model for graft function using preoperative marginal factors in living-donor kidney transplantation.
{Author}: Matsukuma Y;Masutani K;Tanaka S;Tsuchimoto A;Nakano T;Okabe Y;Kakuta Y;Okumi M;Tsuruya K;Nakamura M;Kitazono T;Tanabe K; ;
{Journal}: Clin Exp Nephrol
{Volume}: 23
{Issue}: 11
{Year}: Nov 2019
{Factor}: 2.617
{DOI}: 10.1007/s10157-019-01774-x
{Abstract}: <B>BACKGROUND: </B>Recently, living-donor kidney transplantation from marginal donors has been increasing. However, a simple prediction model for graft function including preoperative marginal factors is limited. Here, we developed and validated a new prediction model for graft function using preoperative marginal factors in living-donor kidney transplantation.<BR><B>METHODS: </B>We retrospectively investigated 343 patients who underwent living-donor kidney transplantation at Kyushu University Hospital (derivation cohort). Low graft function was defined as an estimated glomerular filtration rate of < 45 mL/min/1.73 m2 at 1 year. A prediction model was developed using a multivariable logistic regression model, and verified using data from 232 patients who underwent living-donor kidney transplantation at Tokyo Women's Medical University Hospital (validation cohort).<BR><B>RESULTS: </B>In the derivation cohort, 89 patients (25.9%) had low graft function at 1 year. Donor age, donor-estimated glomerular filtration rate, donor hypertension, and donor/recipient body weight ratio were selected as predictive factors. This model demonstrated modest discrimination (c-statistic = 0.77) and calibration (Hosmer-Lemeshow test, P = 0.83). Furthermore, this model demonstrated good discrimination (c-statistic = 0.76) and calibration (Hosmer-Lemeshow test, P = 0.54) in the validation cohort. Furthermore, donor age, donor-estimated glomerular filtration rate, and donor hypertension were strongly associated with glomerulosclerosis and atherosclerotic vascular changes in the "zero-time" biopsy.<BR><B>CONCLUSIONS: </B>This model using four pre-operative variables will be a simple, but useful guide to estimate graft function at 1 year after kidney transplantation, especially in marginal donors, in the clinical setting.