{Reference Type}: Journal Article
{Title}: Benign acute viral myositis in African migrants: A clinical, serological, and pathological study.
{Author}: Pancheri E;Lanzafame M;Zamò A;Angheben A;Sartoris S;Zorzi A;Boaretti M;Signoretto C;Guglielmi V;Ferrari S;Tonin P;Vattemi G;
{Journal}: Muscle Nerve
{Volume}: 60
{Issue}: 5
{Year}: 11 2019
{Factor}: 3.852
{DOI}: 10.1002/mus.26679
{Abstract}: Several viruses have been described as causes of acquired inflammatory myopathies; however, the mechanisms by which they cause muscle disease are still unclear. The aim of this study was to describe the laboratory features of benign acute myositis in a small case series.<BR>A detailed pathological and serological analysis was performed in five African migrants who developed an acute viral myositis complicated by rhabdomyolysis.<BR>Muscle biopsies clearly documented an inflammatory myopathy with histological features similar to polymyositis including CD8+ T cells surrounding and invading nonnecrotic muscle fibers, CD68+ macrophages and major histocompatibility complex class I antigen upregulation. In addition, positivity for myositis-specific antibodies (MSA), in particular anti-aminoacyl tRNA synthetases, was found in the serum of two patients.<BR>Our study demonstrated that T-cell mediated injury occurs in muscle of patients with acute viral myositis, and that MSA may be present in the serum of these patients.