{Reference Type}: Consensus Development Conference
{Title}: Oligometastatic Prostate Cancer: Results of a Dutch Multidisciplinary Consensus Meeting.
{Author}: Aluwini SS;Mehra N;Lolkema MP;Oprea-Lager DE;Yakar D;Stoevelaar H;van der Poel H; ;Busstra M;de Jong IJ;de Reijke T;de Vries K;Heijmink S;Jenster G;Klaver S;Kneppers J;Lavalaye J;Leyten G;Moonen L;Nagaraj J;Noordzij W;Osanto S;Oving I;Schaake E;Scheenen T;Schoots I;Sedelaar M;Somford D;van den Berkmortel F;van der Hulle T;van der Voort van Zyp J;van Leeuwen P;van Moorselaar J;van Oort I;Vogel W;Westgeest H;
{Journal}: Eur Urol Oncol
{Volume}: 3
{Issue}: 2
{Year}: 04 2020
{Factor}: 8.208
{DOI}: 10.1016/j.euo.2019.07.010
{Abstract}: Oligometastatic prostate cancer (OMPC) is a heterogeneous disease state that is imperfectly understood, and its clinical implications are unclear.<BR>To determine the consensus of a Dutch multidisciplinary expert panel on biological aspects, treatment goals, and management of OMPC in daily clinical practice.<BR>The study comprised a modified Delphi method including an explorative survey with various statements and questions, followed by a consensus meeting to discuss and determine the agreement with revised statements and related items. The panel consisted of 34 Dutch representatives from urology, medical and radiation oncology, radiology, nuclear medicine, and basic research.<BR>Agreement was determined with statements (five-point scale). Consensus was defined as ≥75% panel agreement with a statement.<BR>Consensus existed for 56% of statements. The panel agreed that OMPC comprises a limited metastatic spread in the hormone-sensitive setting, in both the synchronous and the metachronous presentation. Limited metastatic spread was believed to involve three to five metastases and a maximum of two organs. Prostate-specific membrane antigen positron emission tomography/computed tomography scan was currently perceived as the most accurate diagnostic imaging modality. Although there was a consensus that targeted treatment of all metastases in OMPC will delay further dissemination of the disease, opinions on specific treatment regimens were divided. Panel outcomes were limited by the lack of scientific evidence on OMPC.<BR>A multidisciplinary panel reached a consensus that OMPC is a specific disease state requiring a tailored treatment approach. OMPC registries and clinical studies should focus on both the biology and the clinical parameters in relation to optimal treatment strategies in synchronous and metachronous OMPC.<BR>A group of Dutch medical specialists agreed that prostate cancer patients having few metastases may benefit from a new therapeutic approach. Clinical studies need to determine which treatment is best for each specific situation.