{Reference Type}: Comparative Study
{Title}: Comparison of toxicokinetic parameters of a drug and two metabolites following traditional and capillary microsampling in rat.
{Author}: Verhaeghe T;Dillen L;Stieltjes H;Zwart L;Feyen B;
{Journal}: Bioanalysis
{Volume}: 11
{Issue}: 13
{Year}: Jun 2019
{Factor}: 2.695
{DOI}: 10.4155/bio-2019-0085
{Abstract}: Aim: Following the request of a regulatory authority, a rat study was conducted to compare pharmacokinetic parameters from traditional large volume sampling and capillary microsampling. Materials & methods: Rats were dosed with a proprietary compound in three dose groups and blood samples were collected via capillary microsampling (32 μl), immediately followed by traditional large volume sampling (300 μl) up to 24 h postdose. Resulting plasma samples were analyzed for parent drug and two metabolites. AUCs were compared between sampling techniques. Results: There was no statistical difference between AUCs from traditional and microsampling across different doses and analytes. Conclusion: Toxicokinetic parameters generated from plasma collected as a capillary microsample or traditional large volume sample are highly comparable.