{Reference Type}: Journal Article
{Title}: Synthesis and structure activity relationships of a series of 4-amino-1H-pyrazoles as covalent inhibitors of CDK14.
{Author}: Ferguson FM;Doctor ZM;Ficarro SB;Marto JA;Kim ND;Sim T;Gray NS;
{Journal}: Bioorg Med Chem Lett
{Volume}: 29
{Issue}: 15
{Year}: 08 2019 1
{Factor}: 2.94
{DOI}: 10.1016/j.bmcl.2019.05.024
{Abstract}: The TAIRE family of kinases are an understudied branch of the CDK kinase family, that have been implicated in a number of cancers. This manuscript describes the design, synthesis and SAR of covalent CDK14 inhibitors, culminating in identification of FMF-04-159-2, a potent, covalent CDK14 inhibitor with a TAIRE kinase biased selectivity profile.