{Reference Type}: Journal Article
{Title}: Completing the picture of tolazamide polymorphism under extreme conditions: a low-temperature study.
{Author}: Fedorov AY;Rychkov DA;Losev EA;Drebushchak TN;Boldyreva EV;
{Journal}: Acta Crystallogr C Struct Chem
{Volume}: 75
{Issue}: 0
{Year}: 05 2019 1
{Factor}: 1.184
{DOI}: 10.1107/S2053229619005217
{Abstract}: We present the results of an experimental and computational study of structural changes in two polymorphs of tolazamide {systematic name: 1-[(azepan-1-ylamino)carbonyl]-4-methylbenzenesulfonamide}, C14H21N3O3S, on cooling to 100 K and reverse heating. No phase transitions occurred in this temperature range. The anisotropy of the thermal expansion was different for the two polymorphs and differed from that reported previously for the hydrostatic compression. The changes in different intermolecular contacts responsible for the strain anisotropy were analysed. Relative shortening of the contacts was related directly to their initial length and reversely to the steric density around them. Increasing steric density is likely to be the driving force for the conformational ordering of the azepane ring under compression.