{Reference Type}: Journal Article
{Title}: A Comparison Study of Working Memory Deficits between Patients with Methamphetamine-Associated Psychosis and Patients with Schizophrenia.
{Author}: Gan H;Song Z;Xu P;Su H;Pan Y;Zhao M;Liu D;
{Journal}: Shanghai Arch Psychiatry
{Volume}: 30
{Issue}: 3
{Year}: Jun 2018 25
暂无{DOI}: 10.11919/j.issn.1002-0829.217166
{Abstract}: <B>UNASSIGNED: </B>Both patients with methamphetamine-associated psychosis (MAP) and patients with schizophrenia suffer from obvious cognitive deficits in working memory, and this affects the functional prognosis of patients.<BR><B>UNASSIGNED: </B>This study is to investigate the difference of working memory deficits between patients with MAP and patients with schizophrenia, especially the difference of central executive system function, and the relevance of working memory deficits and clinical characteristics.<BR><B>UNASSIGNED: </B>Twenty-eight male patients with MAP and twenty-eight patients with schizophrenia were recruited. The working memory of subjects was evaluated with the n-back task edited and adapted from English language materials. The positive syndrome scale of PANSS and CGI were employed to assess psychotic symptoms and the severity of patients.<BR><B>UNASSIGNED: </B>According to the results of repeated measure variance analysis, it was found that both the between-group variable (group) and within-group variable (n) had significant main effects, and the interaction between the between-group variable and the within-group variable was also significant. After Z-transformation, mean (sd) working memory scores of patients with MAP and schizophrenia were 0.91 (0.77) and -0.91 (2.11) respectively, and the difference between these two groups were statistically significant (F=19.253, p<0.001). The relevance between working memory deficits and clinical characteristics was low in both the patients with MAP and patients with schizophrenia.<BR><B>UNASSIGNED: </B>Patients with MAP were better at regulating, updating, executing and controlling active information than patients with schizophrenia.<BR><B>UNASSIGNED: </B>甲基苯丙胺所致精神病性障碍 （methamphetamine-associated psychosis，MAP） 患者 和精神分裂症患者均存在明显的工作记忆等认知功能 缺陷，并且均影响患者的功能预后。.<BR><B>UNASSIGNED: </B>探讨MAP 患者和精神分裂症患者工作记忆缺陷， 尤其中央执行系统功能的差异，以及工作记忆缺损与 临床特征的相关性。.<BR><B>UNASSIGNED: </B>共入组了28 例男性MAP 患者及28 例男性精神 分裂症患者。应用基于语言材料编制的n-back 任务评 估被试的工作记忆。应用阳性与阴性症状量表（PANSS） 的阳性量表及临床总体印象量表（CGI）评估患者的精 神症状及其严重程度。.<BR><B>UNASSIGNED: </B>对n-back 数据进行重复测验方差分析，结果发 现组间变量（组别）及组内变量（n）的主效应均显著， 组间变量与组内变量的交互作用亦显著。经Z 转换后， MAP 患者及精神分裂症患者的工作记忆成绩分别为 0.91（0.77）和-0.91（2.11），组间差异有统计学意义 （F=19.253，p<0.001）。无论MAP 患者或精神分裂症 患者，其工作记忆缺陷与临床特征均缺乏相关性。.<BR><B>UNASSIGNED: </B>MAP 患者对激活信息的管理、更新及执行控制 能力优于精神分裂症患者。.