{Reference Type}: Comparative Study
{Title}: Autism With and Without Regression: A Two-Year Prospective Longitudinal Study in Two Population-Derived Swedish Cohorts.
{Author}: Thompson L;Gillberg C;Landberg S;Kantzer AK;Miniscalco C;Barnevik Olsson M;Eriksson MA;Fernell E;
{Journal}: J Autism Dev Disord
{Volume}: 49
{Issue}: 6
{Year}: Jun 2019
{Factor}: 4.345
{DOI}: 10.1007/s10803-018-03871-4
{Abstract}: Two community-based cohorts of children with autism spectrum disorder, examined using similar assessment protocols, were pooled (n = 301) and subdivided according to history of regression. Those with regression (n = 62), 20.5% of the combined cohort, were contrasted with those without regression (n = 241) at first assessment (age range 19-60 months) and at 2-year follow-up on a range of measures. The regression group was significantly more functionally impaired, with regard to intellectual function (p < .001), language development (p < .001), and to severity of autism (p < .01) at both T1 and T2. Only 14 (23.3%) had a clearly identified underlying etiology [24 (18.6%) in the non-regressive group]. There were no significant differences between those who had regressed 'from normal' and those who had regressed 'from low' functioning.