{Reference Type}: Journal Article
{Title}: Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery - a sub-analysis of the RIPHeart-Study.
{Author}: Westphal S;Stoppe C;Gruenewald M;Bein B;Renner J;Cremer J;Coburn M;Schaelte G;Boening A;Niemann B;Kletzin F;Roesner J;Strouhal U;Reyher C;Laufenberg-Feldmann R;Ferner M;Brandes IF;Bauer M;Kortgen A;Stehr SN;Wittmann M;Baumgarten G;Struck R;Meyer-Treschan T;Kienbaum P;Heringlake M;Schoen J;Sander M;Treskatsch S;Smul T;Wolwender E;Schilling T;Degenhardt F;Franke A;Mucha S;Tittmann L;Kohlhaas M;Fuernau G;Brosteanu O;Hasenclever D;Zacharowski K;Meybohm P; ;
{Journal}: BMC Cardiovasc Disord
{Volume}: 19
{Issue}: 1
{Year}: 01 2019 24
{Factor}: 2.174
{DOI}: 10.1186/s12872-019-1002-x
{Abstract}: The aim of our study was the identification of genetic variants associated with postoperative complications after cardiac surgery.<BR>We conducted a prospective, double-blind, multicenter, randomized trial (RIPHeart). We performed a genome-wide association study (GWAS) in 1170 patients of both genders (871 males, 299 females) from the RIPHeart-Study cohort. Patients undergoing non-emergent cardiac surgery were included. Primary endpoint comprises a binary composite complication rate covering atrial fibrillation, delirium, non-fatal myocardial infarction, acute renal failure and/or any new stroke until hospital discharge with a maximum of fourteen days after surgery.<BR>A total of 547,644 genotyped markers were available for analysis. Following quality control and adjustment for clinical covariate, one SNP reached genome-wide significance (PHLPP2, rs78064607, p = 3.77 × 10- 8) and 139 (adjusted for all other outcomes) SNPs showed promising association with p < 1 × 10- 5 from the GWAS.<BR>We identified several potential loci, in particular PHLPP2, BBS9, RyR2, DUSP4 and HSPA8, associated with new-onset of atrial fibrillation, delirium, myocardial infarction, acute kidney injury and stroke after cardiac surgery.<BR>The study was registered with ClinicalTrials.gov NCT01067703, prospectively registered on 11 Feb 2010.