{Reference Type}: Journal Article
{Title}: Approaches for generation of anti-leukemia specific T cells.
{Author}: Jin Z;Xu L;Li Y;
{Journal}: Cell Regen
{Volume}: 7
{Issue}: 2
{Year}: Dec 2018
暂无{DOI}: 10.1016/j.cr.2018.09.002
{Abstract}: As three decades ago, it was reported that adoptive T cell immunotherapy by infusion of autologous tumor infiltrating lymphocytes (TILs) mediated objective cancer regression in patients with metastatic melanoma. A new era of T cell immunotherapy arose since the improvement and clinical use of anti-CD19 chimeric antigen receptor T cells (CAR-T) for the treatment of refractory and relapsed B lymphocyte leukemia. However, several challenges and difficulties remain on the way to reach generic and effective T cell immunotherapy, including lacking a generic method for generating anti-leukemia-specific T cells from every patient. Here, we summarize the current methods of generating anti-leukemia-specific T cells, and the promising approaches in the future.