{Reference Type}: Journal Article {Title}: Long-term marginal adaptation and nanoleakage of class V cavity restored with organic filler filled 4-META/MMA-TBB resin. {Author}: Zhang C;Yang B; {Journal}: J Biomed Mater Res B Appl Biomater {Volume}: 107 {Issue}: 6 {Year}: 08 2019 {Factor}: 3.405 {DOI}: 10.1002/jbm.b.34297 {Abstract}: The current restorative materials used for cervical lesions restoration still need to be improved. A low E-modulus restorative material Bondfill SB (group BF) is developed. This study was to evaluate marginal adaptation and nanoleakage expression at dentin bonding interface of BF before and after artificial aging cycling when used for class V cavity restoration in vitro. Cavities were prepared in human premolars and restored with either Bondfill SB or Z100 (group SZ). Quantitative data were analyzed by t-test (α = 0.05). Before cycling, there was no significant differences between groups for perfect margin and modes of failure. After cycling, SZ showed a higher (p = 0.002) perfect margin value (55.08 ± 15.20%) and less (p = 0.01) adhesive failure (35.35 ± 15.02%) to enamel than BF (25.15 ± 12.47% and 61.78 ± 15.41%, respectively). BF exhibited less (p = 0.01) adhesive failure (12.89 ± 5.58%) to dentin than SZ (44.17 ± 17.50%). BF showed more cohesive failures at both enamel (12.01 ± 3.65%) (p < 0.0001) and dentin (9.58 ± 3.14%) (p = 0.02) sides than SZ (0.77 ± 1.21% and 4.68 ± 1.39%, respectively). Transmission electron microscope (TEM) showed that hybrid layers in SZ and BF were around 0.5 μm thick. Before cycling, more silver deposits were found at dentin bonding interface in SZ. After cycling, the deterioration in SZ mostly occurred at the bottom and on the surface of the hybrid layer. While in BF, the deterioration occurred at the bottom of the hybrid layer and in Bondfill SB. BF showed a more reliable dentin bonding after artificial aging and might buffer the cervical stress concentration. Bondfill SB may be a new promising choice for long-term success of cervical lesions restoration. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2050-2056, 2019.